ABSTRACT Food fermentations rely on the application of robust bacterial starter cultures, the majority of which are represented by members of the lactic acid bacteria including Lactococcus lactis and Streptococcus thermophilus.Bacteriophage (or phage) proliferation remains one of the most significant threats to the fermentation industry.Therefore, it is imperative to define the phage ecology of fermented foods and to elucidate the 645 mechanisms by which they recognize and bind to their bacterial hosts.Through a combination of functional and comparative genomics and structural analysis of the phage-host interactome, it is now possible to link the genotypes of strains of certain bacterial species to the chemical composition/structure of Walk the associated cell wall polysaccharides (CWPS).
In this paper, I discuss how the identification of common host recognition and binding strategies facilitates the development of rational starter culture systems and the implications of these findings in the context of sustainable food production systems.